Potential Risks of Nitric Oxide Inhibition in Spinal Cord Injury
نویسندگان
چکیده
منابع مشابه
Spinal cord infarcts during long-term inhibition of nitric oxide synthase in rats.
BACKGROUND AND PURPOSE Chronic hypertension is a major predisposing factor for stroke in humans. It has recently been shown that long-term inhibition of nitric oxide synthase activity causes a gradual time-dependent increase in arterial blood pressure in rats. We used this new animal model of chronic hypertension to study the occurrence and spatial features of infarcts in the central nervous sy...
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Acute spinal cord injury (SCI) is two-step process that first involves the primary mechanical injury and then the secondary injury is induced by various biochemical reactions. Apoptosis is one of secondary SCI mechanisms and it is thought to play an important role for the delayed neuronal injury. The enhanced formation of nitric oxide (NO) via inducible nitric oxide synthase (iNOS) has been imp...
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Recently, arginase is suggested to regulate nitric oxide production by competing with nitric oxide synthase for the same substrate, L-arginine, in experimental asthma. We investigated the role of arginase and its relationship to nitric oxide production after spinal cord injury. Rats were subjected to laminectomy and complete transection of their spinal cords (injury group) or laminectomy only (...
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ژورنال
عنوان ژورنال: The Journal of Spinal Cord Medicine
سال: 2007
ISSN: 1079-0268,2045-7723
DOI: 10.1080/10790268.2007.11753906